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The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.

Publication ,  Journal Article
Lien, LF; Haqq, AM; Arlotto, M; Slentz, CA; Muehlbauer, MJ; McMahon, RL; Rochon, J; Gallup, D; Bain, JR; Ilkayeva, O; Wenner, BR; Stevens, RD ...
Published in: OMICS
February 2009

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) Project uses comprehensive metabolic profiling to probe biochemical mechanisms of weight loss in humans. Measurements at baseline, 2 and 4 weeks, 6 and 12 months included diet, body composition, metabolic rate, hormones, and 80 intermediary metabolites measured by mass spectrometry. In 27 obese adults in a behavioral weight loss intervention, median weight decreased 13.9 lb over the first 6 months, then reverted towards baseline by 12 months. Insulin resistance (HOMA) was partially ameliorated in the first 6 months and showed sustained improvement at 12 months despite weight regain. Ghrelin increased with weight loss and reverted to baseline, whereas leptin and PYY fell at 6 months and remained persistently low. NPY levels did not change. Factors possibly contributing to sustained improvement in insulin sensitivity despite weight regain include adiponectin (increased by 12 months), IGF-1 (increased during weight loss and continued to increase during weight regain), and visceral fat (fell at 6 months but did not change thereafter). We observed a persistent reduction in free fatty acids, branched chain amino acids, and related metabolites that may contribute to improved insulin action. These findings provide evidence for sustained benefits of weight loss in obese humans and insights into mechanisms.

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Published In

OMICS

DOI

EISSN

1557-8100

Publication Date

February 2009

Volume

13

Issue

1

Start / End Page

21 / 35

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Peptide YY
  • Obesity
  • Neuropeptide Y
  • Middle Aged
  • Leptin
  • Insulin-Like Growth Factor I
  • Insulin Resistance
  • Humans
 

Citation

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Lien, L. F., Haqq, A. M., Arlotto, M., Slentz, C. A., Muehlbauer, M. J., McMahon, R. L., … Svetkey, L. P. (2009). The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. OMICS, 13(1), 21–35. https://doi.org/10.1089/omi.2008.0035
Lien, Lillian F., Andrea M. Haqq, Michelle Arlotto, Cris A. Slentz, Michael J. Muehlbauer, Ross L. McMahon, James Rochon, et al. “The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.OMICS 13, no. 1 (February 2009): 21–35. https://doi.org/10.1089/omi.2008.0035.
Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, et al. The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. OMICS. 2009 Feb;13(1):21–35.
Lien, Lillian F., et al. “The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.OMICS, vol. 13, no. 1, Feb. 2009, pp. 21–35. Pubmed, doi:10.1089/omi.2008.0035.
Lien LF, Haqq AM, Arlotto M, Slentz CA, Muehlbauer MJ, McMahon RL, Rochon J, Gallup D, Bain JR, Ilkayeva O, Wenner BR, Stevens RD, Millington DS, Muoio DM, Butler MD, Newgard CB, Svetkey LP. The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. OMICS. 2009 Feb;13(1):21–35.
Journal cover image

Published In

OMICS

DOI

EISSN

1557-8100

Publication Date

February 2009

Volume

13

Issue

1

Start / End Page

21 / 35

Location

United States

Related Subject Headings

  • Weight Loss
  • Weight Gain
  • Peptide YY
  • Obesity
  • Neuropeptide Y
  • Middle Aged
  • Leptin
  • Insulin-Like Growth Factor I
  • Insulin Resistance
  • Humans