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Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis.

Publication ,  Journal Article
Li, JS; Baker-Smith, CM; Smith, PB; Hasselblad, V; Murphy, MD; Califf, RM; Benjamin, DK
Published in: Clin Pharmacol Ther
September 2008

Angiotensin-converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.(1) ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilatory and natriuretic properties of bradykinin; they also alter the metabolism of other vasoactive substances.(2) Through these mechanisms, ACE inhibitors decrease systemic vascular resistance and promote natriuresis without increasing heart rate. This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response.

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Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

September 2008

Volume

84

Issue

3

Start / End Page

315 / 319

Location

United States

Related Subject Headings

  • White People
  • Randomized Controlled Trials as Topic
  • Pharmacology & Pharmacy
  • Male
  • Hypertension
  • Humans
  • Female
  • Child
  • Blood Pressure
  • Black People
 

Citation

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Li, J. S., Baker-Smith, C. M., Smith, P. B., Hasselblad, V., Murphy, M. D., Califf, R. M., & Benjamin, D. K. (2008). Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clin Pharmacol Ther, 84(3), 315–319. https://doi.org/10.1038/clpt.2008.113
Li, J. S., C. M. Baker-Smith, P. B. Smith, V. Hasselblad, M. D. Murphy, R. M. Califf, and D. K. Benjamin. “Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis.Clin Pharmacol Ther 84, no. 3 (September 2008): 315–19. https://doi.org/10.1038/clpt.2008.113.
Li JS, Baker-Smith CM, Smith PB, Hasselblad V, Murphy MD, Califf RM, et al. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clin Pharmacol Ther. 2008 Sep;84(3):315–9.
Li, J. S., et al. “Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis.Clin Pharmacol Ther, vol. 84, no. 3, Sept. 2008, pp. 315–19. Pubmed, doi:10.1038/clpt.2008.113.
Li JS, Baker-Smith CM, Smith PB, Hasselblad V, Murphy MD, Califf RM, Benjamin DK. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clin Pharmacol Ther. 2008 Sep;84(3):315–319.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

September 2008

Volume

84

Issue

3

Start / End Page

315 / 319

Location

United States

Related Subject Headings

  • White People
  • Randomized Controlled Trials as Topic
  • Pharmacology & Pharmacy
  • Male
  • Hypertension
  • Humans
  • Female
  • Child
  • Blood Pressure
  • Black People