Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis.

Journal Article (Journal Article;Review)

Angiotensin-converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.(1) ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilatory and natriuretic properties of bradykinin; they also alter the metabolism of other vasoactive substances.(2) Through these mechanisms, ACE inhibitors decrease systemic vascular resistance and promote natriuresis without increasing heart rate. This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response.

Full Text

Duke Authors

Cited Authors

  • Li, JS; Baker-Smith, CM; Smith, PB; Hasselblad, V; Murphy, MD; Califf, RM; Benjamin, DK

Published Date

  • September 2008

Published In

Volume / Issue

  • 84 / 3

Start / End Page

  • 315 - 319

PubMed ID

  • 18548000

Pubmed Central ID

  • PMC2614386

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2008.113


  • eng

Conference Location

  • United States