Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.

Published

Journal Article

BACKGROUND: Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification. METHODS: Horizon 1 of the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Study was conceived to apply emerging molecular techniques to existing data sets to characterize mechanistic diversity underlying complex human diseases, response to therapy, and prognosis. No previous studies have applied multiple, complementary molecular techniques in combination with well-developed clinical risk models to refine cardiovascular risk prediction. The MURDOCK Cardiovascular Disease Study will assess molecular profiles integrated with clinical data in "clinomic" profiles for cardiovascular risk classification. CONCLUSION: Herein, we describe the design of and rationale for the MURDOCK Cardiovascular Disease Study.

Full Text

Duke Authors

Cited Authors

  • Shah, SH; Granger, CB; Hauser, ER; Kraus, WE; Sun, J-L; Pieper, K; Nelson, CL; Delong, ER; Califf, RM; Newby, LK; MURDOCK Horizon 1 Cardiovascular Disease Investigators,

Published Date

  • September 2010

Published In

Volume / Issue

  • 160 / 3

Start / End Page

  • 371 - 379.e2

PubMed ID

  • 20826242

Pubmed Central ID

  • 20826242

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2010.06.051

Language

  • eng

Conference Location

  • United States