Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.
Published
Journal Article
BACKGROUND: Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification. METHODS: Horizon 1 of the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Study was conceived to apply emerging molecular techniques to existing data sets to characterize mechanistic diversity underlying complex human diseases, response to therapy, and prognosis. No previous studies have applied multiple, complementary molecular techniques in combination with well-developed clinical risk models to refine cardiovascular risk prediction. The MURDOCK Cardiovascular Disease Study will assess molecular profiles integrated with clinical data in "clinomic" profiles for cardiovascular risk classification. CONCLUSION: Herein, we describe the design of and rationale for the MURDOCK Cardiovascular Disease Study.
Full Text
Duke Authors
- Califf, Robert M.
- DeLong, Elizabeth Ray
- Granger, Christopher Bull
- Hauser, Elizabeth Rebecca
- Kraus, William Erle
- Newby, Laura Kristin
- Shah, Svati Hasmukh
Cited Authors
- Shah, SH; Granger, CB; Hauser, ER; Kraus, WE; Sun, J-L; Pieper, K; Nelson, CL; Delong, ER; Califf, RM; Newby, LK; MURDOCK Horizon 1 Cardiovascular Disease Investigators,
Published Date
- September 2010
Published In
Volume / Issue
- 160 / 3
Start / End Page
- 371 - 379.e2
PubMed ID
- 20826242
Pubmed Central ID
- 20826242
Electronic International Standard Serial Number (EISSN)
- 1097-6744
Digital Object Identifier (DOI)
- 10.1016/j.ahj.2010.06.051
Language
- eng
Conference Location
- United States