Quantitative effects of contrast enhanced CT attenuation correction on PET SUV measurements.


Journal Article

PURPOSE: The presence of contrast materials on computed tomography (CT) images can cause problems in the attenuation correction of positron emission tomography (PET) images. These are because of errors converting the CT attenuation of contrast to 511-keV attenuation and by the change in tissue enhancement over the duration of the PET emission scan. Newer CT-based attenuation correction (CTAC) algorithms have been developed to reduce these errors. METHODS: To evaluate the effectiveness of the modified CTAC technique, we performed a retrospective analysis on 20 patients, comparing PET images using unenhanced and contrast-enhanced CT scans for attenuation correction. A phantom study was performed to simulate the effects of contrast on radiotracer concentration measurements. RESULTS: There was a maximum difference in calculated radiotracer concentrations of 5.9% within the retrospective data and 7% within the phantom data. CONCLUSION: Using a CTAC algorithm that de-emphasizes high-density areas, contrast-enhanced CT can be used for attenuation mapping without significant errors in quantitation.

Full Text

Duke Authors

Cited Authors

  • Bunyaviroch, T; Turkington, TG; Wong, TZ; Wilson, JW; Colsher, JG; Coleman, RE

Published Date

  • March 2008

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 107 - 113

PubMed ID

  • 18097724

Pubmed Central ID

  • 18097724

International Standard Serial Number (ISSN)

  • 1536-1632

Digital Object Identifier (DOI)

  • 10.1007/s11307-007-0126-z


  • eng

Conference Location

  • United States