Changes in plasma volume associated with mental stress ischemia in patients with coronary artery disease.

Journal Article (Journal Article)

Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radionuclide ventriculography during a multiple stress challenge. Plasma volume was assessed during rest and at the end of the stress task. Flow-mediated dilatation was also measured. Controlling for endothelial function and medications, patients with ischemia had greater reductions in plasma volume than non-ischemic patients. Reduced plasma volume may be one mechanism by which mental stress may increase the risk for acute coronary events.

Full Text

Duke Authors

Cited Authors

  • Bacon, SL; Sherwood, A; Hinderliter, AL; Coleman, RE; Waugh, R; Blumenthal, JA

Published Date

  • August 2006

Published In

Volume / Issue

  • 61 / 2

Start / End Page

  • 143 - 148

PubMed ID

  • 16253364

International Standard Serial Number (ISSN)

  • 0167-8760

Digital Object Identifier (DOI)

  • 10.1016/j.ijpsycho.2005.09.001


  • eng

Conference Location

  • Netherlands