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Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.

Publication ,  Journal Article
Hinderliter, AL; Blumenthal, JA; Waugh, R; Chilukuri, M; Sherwood, A
Published in: Am J Hypertens
January 2004

BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline in BP and early remodeling of the resistance vessels in African Americans. METHODS: To further evaluate the contributions of diurnal BP variation and vascular remodeling to ethnic differences in left ventricular geometry, we measured ambulatory BP, systemic hemodynamics, minimum forearm vascular resistance, and left ventricular structure in a biracial sample of 171 men and women between the ages of 25 and 45 years. RESULTS: Despite similar resting BPs, African Americans had a greater indexed peripheral resistance, a greater minimal forearm vascular resistance, and a smaller nocturnal decline in BP than white subjects. African Americans also had a greater left ventricular relative wall thickness (0.41 +/- 0.07 v 0.38 +/- 0.08, P =.048) and a trend toward a greater indexed left ventricular mass (41.1 +/- 8.7 v 38.6 +/- 8.6 g/m(2.7), P =.087). Ethnic differences in relative wall thickness were no longer significant when adjusted for either indexed peripheral resistance (P =.173) or sleep systolic BP (P =.124). CONCLUSIONS: In our cohort of young men and women, African Americans had a greater left ventricular relative wall thickness than whites with similar levels of resting BP. This early concentric remodeling of the left ventricle in African Americans may be mediated, in part, by hemodynamic influences, including a greater peripheral vascular resistance and a smaller nocturnal decline in BP.

Duke Scholars

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

January 2004

Volume

17

Issue

1

Start / End Page

43 / 49

Location

United States

Related Subject Headings

  • White People
  • Vascular Resistance
  • United States
  • Middle Aged
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Hemodynamics
  • Female
  • Echocardiography
 

Citation

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ICMJE
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Hinderliter, A. L., Blumenthal, J. A., Waugh, R., Chilukuri, M., & Sherwood, A. (2004). Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation. Am J Hypertens, 17(1), 43–49. https://doi.org/10.1016/j.amjhyper.2003.08.007
Hinderliter, Alan L., James A. Blumenthal, Robert Waugh, Mohan Chilukuri, and Andrew Sherwood. “Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.Am J Hypertens 17, no. 1 (January 2004): 43–49. https://doi.org/10.1016/j.amjhyper.2003.08.007.
Hinderliter AL, Blumenthal JA, Waugh R, Chilukuri M, Sherwood A. Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation. Am J Hypertens. 2004 Jan;17(1):43–9.
Hinderliter, Alan L., et al. “Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.Am J Hypertens, vol. 17, no. 1, Jan. 2004, pp. 43–49. Pubmed, doi:10.1016/j.amjhyper.2003.08.007.
Hinderliter AL, Blumenthal JA, Waugh R, Chilukuri M, Sherwood A. Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation. Am J Hypertens. 2004 Jan;17(1):43–49.
Journal cover image

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

January 2004

Volume

17

Issue

1

Start / End Page

43 / 49

Location

United States

Related Subject Headings

  • White People
  • Vascular Resistance
  • United States
  • Middle Aged
  • Male
  • Hypertrophy, Left Ventricular
  • Humans
  • Hemodynamics
  • Female
  • Echocardiography