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Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Publication ,  Journal Article
Hoffman, BM; Babyak, MA; Craighead, WE; Sherwood, A; Doraiswamy, PM; Coons, MJ; Blumenthal, JA
Published in: Psychosom Med
2011

OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a) supervised exercise; b) home-based exercise; c) sertraline; or d) placebo pill. We examined two outcomes measured at 1-year follow-up (i.e., 16 months post randomization): 1) continuous Hamilton Depression Rating Scale score; and 2) MDD status (depressed; partial remission; full remission) in 172 available participants (85% of the original cohort). Regression analyses were performed to examine the effects of treatment group assignment, as well as follow-up antidepressant medication use and self-reported exercise (Godin Leisure-Time Exercise Questionnaire), on the two outcomes. RESULTS: In the original study, patients receiving exercise achieved similar benefits compared with those receiving sertraline. At the time of the 1-year follow-up, rates of MDD remission increased from 46% at post treatment to 66% for participants available for follow-up. Neither initial treatment group assignment nor antidepressant medication use during the follow-up period were significant predictors of MDD remission at 1 year. However, regular exercise during the follow-up period predicted both Hamilton Depression Rating Scale scores and MDD diagnosis at 1 year. This relationship was curvilinear, with the association concentrated between 0 minute and 180 minutes of weekly exercise. CONCLUSION: The effects of aerobic exercise on MDD remission seem to be similar to sertraline after 4 months of treatment; exercise during the follow-up period seems to extend the short-term benefits of exercise and may augment the benefits of antidepressant use. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00331305.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2011

Volume

73

Issue

2

Start / End Page

127 / 133

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Social Support
  • Sertraline
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, B. M., Babyak, M. A., Craighead, W. E., Sherwood, A., Doraiswamy, P. M., Coons, M. J., & Blumenthal, J. A. (2011). Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med, 73(2), 127–133. https://doi.org/10.1097/PSY.0b013e31820433a5
Hoffman, Benson M., Michael A. Babyak, W Edward Craighead, Andrew Sherwood, P Murali Doraiswamy, Michael J. Coons, and James A. Blumenthal. “Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.Psychosom Med 73, no. 2 (2011): 127–33. https://doi.org/10.1097/PSY.0b013e31820433a5.
Hoffman BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, et al. Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med. 2011;73(2):127–33.
Hoffman, Benson M., et al. “Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.Psychosom Med, vol. 73, no. 2, 2011, pp. 127–33. Pubmed, doi:10.1097/PSY.0b013e31820433a5.
Hoffman BM, Babyak MA, Craighead WE, Sherwood A, Doraiswamy PM, Coons MJ, Blumenthal JA. Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study. Psychosom Med. 2011;73(2):127–133.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

2011

Volume

73

Issue

2

Start / End Page

127 / 133

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Social Support
  • Sertraline
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Follow-Up Studies