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Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.

Publication ,  Journal Article
Babyak, MA; Blumenthal, JA; Hinderliter, A; Hoffman, B; Waugh, RA; Coleman, RE; Sherwood, A
Published in: Am J Cardiol
January 1, 2010

Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to examine the prospective relation of mental stress on clinical outcomes in a sample of 138 patients with stable coronary artery disease. Patients underwent mental stress testing and were followed for a median of 5.9 years to assess the occurrence of the combined end point of myocardial infarction or all-cause mortality. There were 32 events (17 nonfatal myocardial infarctions and 15 deaths) over the follow-up period. Of the 26 patients who exhibited myocardial ischemia during mental stress testing, 11 (42%) sustained subsequent clinical events, compared to 21 of the 112 patients (19%) who showed no mental stress-induced ischemia. LVEF change during mental stress was also related to the clinical events in a graded, continuous fashion, with each 4% decrease from the LVEF at rest associated with an adjusted hazard ratio of 1.7, (95% confidence interval 1.1 to 2.6, p = 0.011). In conclusion, reductions in the LVEF during mental stress are prospectively associated with adverse clinical outcomes.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 1, 2010

Volume

105

Issue

1

Start / End Page

25 / 28

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Stress, Psychological
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Gated Blood-Pool Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Babyak, M. A., Blumenthal, J. A., Hinderliter, A., Hoffman, B., Waugh, R. A., Coleman, R. E., & Sherwood, A. (2010). Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease. Am J Cardiol, 105(1), 25–28. https://doi.org/10.1016/j.amjcard.2009.08.647
Babyak, Michael A., James A. Blumenthal, Alan Hinderliter, Benson Hoffman, Robert A. Waugh, R Edward Coleman, and Andrew Sherwood. “Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.Am J Cardiol 105, no. 1 (January 1, 2010): 25–28. https://doi.org/10.1016/j.amjcard.2009.08.647.
Babyak MA, Blumenthal JA, Hinderliter A, Hoffman B, Waugh RA, Coleman RE, et al. Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease. Am J Cardiol. 2010 Jan 1;105(1):25–8.
Babyak, Michael A., et al. “Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.Am J Cardiol, vol. 105, no. 1, Jan. 2010, pp. 25–28. Pubmed, doi:10.1016/j.amjcard.2009.08.647.
Babyak MA, Blumenthal JA, Hinderliter A, Hoffman B, Waugh RA, Coleman RE, Sherwood A. Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease. Am J Cardiol. 2010 Jan 1;105(1):25–28.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 1, 2010

Volume

105

Issue

1

Start / End Page

25 / 28

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Stress, Psychological
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Gated Blood-Pool Imaging