Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence.

Journal Article (Journal Article;Review)

BACKGROUND: Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease. PURPOSE: The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes. METHODS: A systematic literature search in the period of 2002-2009 for PTSD, cardiovascular disease, and metabolic disease was conducted. RESULTS: The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers. CONCLUSIONS: Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research.

Full Text

Duke Authors

Cited Authors

  • Dedert, EA; Calhoun, PS; Watkins, LL; Sherwood, A; Beckham, JC

Published Date

  • February 2010

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 61 - 78

PubMed ID

  • 20174903

Pubmed Central ID

  • PMC3219414

Electronic International Standard Serial Number (EISSN)

  • 1532-4796

Digital Object Identifier (DOI)

  • 10.1007/s12160-010-9165-9


  • eng

Conference Location

  • England