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Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.

Publication ,  Journal Article
Sherwood, A; Park, SB; Hughes, JW; Blumenthal, JA; Hinderliter, A; Trivedi, R; McFetridge-Durdle, J
Published in: Menopause
March 2010

OBJECTIVE: After menopause, women are at an increased risk of cardiovascular disease. The present study assessed cardiovascular hemodynamics in premenopausal versus postmenopausal women, with a focus on systemic vascular resistance (SVR) at rest and during stress. Sympathetic nervous system activity and cardiovascular adrenergic receptor (AR) function were also examined. METHODS: A total of 90 women (45 premenopausal and 45 postmenopausal) completed a laboratory protocol composed of a resting baseline and four mental stress tasks. Measurements included blood pressure, cardiac output, SVR, and plasma catecholamine level. In addition, alpha- and beta-AR responsiveness to the infusion of selective pharmacological agonists was assessed. RESULTS: Compared with premenopausal women, postmenopausal women were characterized by similar blood pressure but lower cardiac output and higher SVR, both at rest and during stress (Ps < 0.05). Postmenopausal women also had higher baseline plasma norepinephrine levels (P = 0.007) and reduced beta-AR responsiveness (P = 0.02), although differences in beta-AR responsiveness may have been confounded by aging effects. CONCLUSIONS: After menopause, women exhibit altered sympathetic nervous system activity and a sustained increase in hemodynamic load that may contribute to pathological structural and functional changes in the heart and blood vessels.

Duke Scholars

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

March 2010

Volume

17

Issue

2

Start / End Page

403 / 409

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Sympathetic Nervous System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Premenopause
  • Postmenopause
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans
  • Hemodynamics
 

Citation

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Sherwood, A., Park, S. B., Hughes, J. W., Blumenthal, J. A., Hinderliter, A., Trivedi, R., & McFetridge-Durdle, J. (2010). Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause, 17(2), 403–409. https://doi.org/10.1097/gme.0b013e3181b9b061
Sherwood, Andrew, Sat Byul Park, Joel W. Hughes, James A. Blumenthal, Alan Hinderliter, Ranak Trivedi, and Judith McFetridge-Durdle. “Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.Menopause 17, no. 2 (March 2010): 403–9. https://doi.org/10.1097/gme.0b013e3181b9b061.
Sherwood A, Park SB, Hughes JW, Blumenthal JA, Hinderliter A, Trivedi R, et al. Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause. 2010 Mar;17(2):403–9.
Sherwood, Andrew, et al. “Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.Menopause, vol. 17, no. 2, Mar. 2010, pp. 403–09. Pubmed, doi:10.1097/gme.0b013e3181b9b061.
Sherwood A, Park SB, Hughes JW, Blumenthal JA, Hinderliter A, Trivedi R, McFetridge-Durdle J. Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause. 2010 Mar;17(2):403–409.

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

March 2010

Volume

17

Issue

2

Start / End Page

403 / 409

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Sympathetic Nervous System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Premenopause
  • Postmenopause
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans
  • Hemodynamics