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Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers.

Publication ,  Journal Article
Elliott, L; Loomis, D; Dement, J; Hein, MJ; Richardson, D; Stayner, L
Published in: Occup Environ Med
June 2012

OBJECTIVES: Studies of workers in two US cohorts of asbestos textile workers exposed to chrysotile (North Carolina (NC) and South Carolina (SC)) found increasing risk of lung cancer mortality with cumulative fibre exposure. However, the risk appeared to increase more steeply in SC, possibly due to differences in study methods. The authors conducted pooled analyses of the cohorts and investigated the exposure-disease relationship using uniform cohort inclusion criteria and statistical methods. METHODS: Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Poisson regression was used to estimate the exposure-response relationship between asbestos and lung cancer, using both exponential and linear relative rate models adjusted for age, sex, race, birth cohort and decade of follow-up. RESULTS: The cohort included 6136 workers, contributing 218,631 person-years of observation and 3356 deaths. Cumulative exposures at the four study facilities varied considerably. The pooled relative rate for lung cancer, comparing 100 f-yr/ml to 0 f-yr/ml, was 1.11 (95% CI 1.06 to 1.16) for the combined cohort, with different effects in the NC cohort (RR=1.10, 95% CI 1.03 to 1.16) and the SC cohort (RR = 1.67, 95% CI 1.44 to 1.93). CONCLUSIONS: Increased rates of lung cancer were significantly associated with cumulative fibre exposure overall and in both the Carolina asbestos-textile cohorts. Previously reported differences in exposure-response between the cohorts do not appear to be related to inclusion criteria or analytical methods.

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Published In

Occup Environ Med

DOI

EISSN

1470-7926

Publication Date

June 2012

Volume

69

Issue

6

Start / End Page

385 / 390

Location

England

Related Subject Headings

  • Young Adult
  • Time Factors
  • Textile Industry
  • South Carolina
  • Regression Analysis
  • Poisson Distribution
  • Occupational Exposure
  • Occupational Diseases
  • North Carolina
  • Multivariate Analysis
 

Citation

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Elliott, L., Loomis, D., Dement, J., Hein, M. J., Richardson, D., & Stayner, L. (2012). Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers. Occup Environ Med, 69(6), 385–390. https://doi.org/10.1136/oemed-2011-100229
Elliott, Leslie, Dana Loomis, John Dement, Misty J. Hein, David Richardson, and Leslie Stayner. “Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers.Occup Environ Med 69, no. 6 (June 2012): 385–90. https://doi.org/10.1136/oemed-2011-100229.
Elliott L, Loomis D, Dement J, Hein MJ, Richardson D, Stayner L. Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers. Occup Environ Med. 2012 Jun;69(6):385–90.
Elliott, Leslie, et al. “Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers.Occup Environ Med, vol. 69, no. 6, June 2012, pp. 385–90. Pubmed, doi:10.1136/oemed-2011-100229.
Elliott L, Loomis D, Dement J, Hein MJ, Richardson D, Stayner L. Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers. Occup Environ Med. 2012 Jun;69(6):385–390.

Published In

Occup Environ Med

DOI

EISSN

1470-7926

Publication Date

June 2012

Volume

69

Issue

6

Start / End Page

385 / 390

Location

England

Related Subject Headings

  • Young Adult
  • Time Factors
  • Textile Industry
  • South Carolina
  • Regression Analysis
  • Poisson Distribution
  • Occupational Exposure
  • Occupational Diseases
  • North Carolina
  • Multivariate Analysis