CD22 and Siglec-G in B cell function and tolerance.

Journal Article (Journal Article;Review)

The immune system has evolved into two main arms: the primitive innate arm that is the first line of defense but relatively short-lived and broad acting; and the advanced adaptive arm that generates immunological memory, allowing rapid, specific recall responses. T cell-independent type-2 (TI-2) antigens (Ags) invoke innate immune responses. However, due to its 'at the ready' nature, how the innate arm of the immune system maintains tolerance to potentially abundant host TI-2 Ags remains elusive. Therefore, it is important to define the mechanisms that establish innate immune tolerance. This review highlights recent insights into B cell tolerance to theoretical self TI-2 Ags, and examines how the B cell-restricted sialic acid binding Ig-like lectins (Siglecs), CD22 and Siglec-G, might contribute to this process.

Full Text

Duke Authors

Cited Authors

  • Poe, JC; Tedder, TF

Published Date

  • August 2012

Published In

Volume / Issue

  • 33 / 8

Start / End Page

  • 413 - 420

PubMed ID

  • 22677186

Pubmed Central ID

  • PMC3407281

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England