Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI.

Journal Article (Journal Article;Multicenter Study)

Levels of four urinary F(2)-isoprostanes (F(2)-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic whites (NHWs), and 275 Hispanic whites (HWs). F(2)-IsoP isomers - iPF2a-III, 2,3-dinor-iPF2a-III, iPF2a-VI, and 8,12-iso-iPF2a-VI - were measured in 854 urine samples using liquid chromatography with tandem mass spectrometry detection. In AAs, levels of all four F(2)-IsoPs were lower compared with NHWs and HWs (P values <0.05). When stratified by BMI, this gap was not observed among participants with normal BMI but appeared among overweight participants and increased among obese participants. Examining the slopes of the associations between BMI and F(2)-IsoPs showed no association between these variables among AAs (P values >0.2), and positive associations among whites (P values <0.05). Taking into account that positive cross-sectional associations between systemic F(2)-IsoP levels and BMI have been consistently demonstrated in many study populations, the lack of such an association among AAs reveals a new facet of racial/ethnic differences in obesity-related risk profiles.

Full Text

Duke Authors

Cited Authors

  • Il'yasova, D; Wang, F; Spasojevic, I; Base, K; D'Agostino, RB; Wagenknecht, LE

Published Date

  • October 2012

Published In

Volume / Issue

  • 20 / 10

Start / End Page

  • 2147 - 2150

PubMed ID

  • 22836686

Pubmed Central ID

  • PMC3458154

Electronic International Standard Serial Number (EISSN)

  • 1930-739X

Digital Object Identifier (DOI)

  • 10.1038/oby.2012.170


  • eng

Conference Location

  • United States