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Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency.

Publication ,  Journal Article
Steele, SU; Cheah, SM; Veerapandiyan, A; Gallentine, W; Smith, EC; Mikati, MA
Published in: Epilepsy Behav
August 2012

Seizure semiology and electroencephalographic (EEG) manifestations of autoimmune-mediated cerebral folate deficiency (CFD) before and after therapy have yet to be fully characterized. Here, we report these findings in two such patients. Our first patient presented with the novel manifestation of infantile spasms at the age of 3months, while the second developed the previously reported initial onset of tonic seizures with static developmental delay, but subsequently manifested the novel finding of electrical status epilepticus in sleep at the age of 15years. Awareness of these new manifestations, together with the previously reported manifestations of developmental delay, seizure onset during the first 2years of life, occurrence of tonic, myoclonic-astatic, absence, and generalized tonic-clonic seizures, with an EEG of generalized spike-slow waves and multifocal spikes, is important to increase the index of suspicion of this treatable disorder.

Duke Scholars

Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

August 2012

Volume

24

Issue

4

Start / End Page

507 / 512

Location

United States

Related Subject Headings

  • Young Adult
  • Seizures
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Folic Acid Deficiency
  • Folate Receptor 1
  • Female
  • Electroencephalography
  • Child
 

Citation

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Steele, S. U., Cheah, S. M., Veerapandiyan, A., Gallentine, W., Smith, E. C., & Mikati, M. A. (2012). Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency. Epilepsy Behav, 24(4), 507–512. https://doi.org/10.1016/j.yebeh.2012.05.021
Steele, Sonya U., Sue Mei Cheah, Aravindhan Veerapandiyan, William Gallentine, Edward C. Smith, and Mohamad A. Mikati. “Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency.Epilepsy Behav 24, no. 4 (August 2012): 507–12. https://doi.org/10.1016/j.yebeh.2012.05.021.
Steele SU, Cheah SM, Veerapandiyan A, Gallentine W, Smith EC, Mikati MA. Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency. Epilepsy Behav. 2012 Aug;24(4):507–12.
Steele, Sonya U., et al. “Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency.Epilepsy Behav, vol. 24, no. 4, Aug. 2012, pp. 507–12. Pubmed, doi:10.1016/j.yebeh.2012.05.021.
Steele SU, Cheah SM, Veerapandiyan A, Gallentine W, Smith EC, Mikati MA. Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency. Epilepsy Behav. 2012 Aug;24(4):507–512.
Journal cover image

Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

August 2012

Volume

24

Issue

4

Start / End Page

507 / 512

Location

United States

Related Subject Headings

  • Young Adult
  • Seizures
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Folic Acid Deficiency
  • Folate Receptor 1
  • Female
  • Electroencephalography
  • Child