Motivations for genetic testing for lung cancer risk among young smokers.

Journal Article (Journal Article)


To examine why young people might want to undergo genetic susceptibility testing for lung cancer despite knowing that tested gene variants are associated with small increases in disease risk.


The authors used a mixed-method approach to evaluate motives for and against genetic testing and the association between these motivations and testing intentions in 128 college students who smoke.


Exploratory factor analysis yielded four reliable factors: Test Scepticism, Test Optimism, Knowledge Enhancement and Smoking Optimism. Test Optimism and Knowledge Enhancement correlated positively with intentions to test in bivariate and multivariate analyses (ps<0.001). Test Scepticism correlated negatively with testing intentions in multivariate analyses (p<0.05). Open-ended questions assessing testing motivations generally replicated themes of the quantitative survey.


In addition to learning about health risks, young people may be motivated to seek genetic testing for reasons, such as gaining knowledge about new genetic technologies more broadly.

Full Text

Duke Authors

Cited Authors

  • O'Neill, SC; Lipkus, IM; Sanderson, SC; Shepperd, J; Docherty, S; McBride, CM

Published Date

  • November 2013

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 406 - 411

PubMed ID

  • 22744911

Pubmed Central ID

  • PMC3586780

Electronic International Standard Serial Number (EISSN)

  • 1468-3318

International Standard Serial Number (ISSN)

  • 0964-4563

Digital Object Identifier (DOI)

  • 10.1136/tobaccocontrol-2011-050306


  • eng