Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.
Journal Article (Journal Article)
Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)-infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed patients, but data on the prevalence of colonization are very limited in sub-Saharan Africa, where the majority of persons living with HIV reside. Our objective was to describe the epidemiology of P. jirovecii colonization among HIV-positive patients in a cross-sectional, hospital-based study of patients admitted with suspected pneumonia in Kampala, Uganda. P. jirovecii was detectable in bronchoalveolar lavage fluid from 7 (6%) of 124 consecutive patients with non-Pneumocystis pneumonia. Colonization was not associated with patient demographic or clinical information. This prevalence is substantially lower than in published studies in the developed world and suggests that there is a limited reservoir of organisms for clinical infections in this Ugandan population. These findings may partially explain the low incidence of Pneumocystis pneumonia in Uganda and other sub-Saharan African countries.
Full Text
Duke Authors
Cited Authors
- Taylor, SM; Meshnick, SR; Worodria, W; Andama, A; Davis, JL; Cattamanchi, A; den Boon, S; Yoo, SD; Goodman, CD; Huang, L; International HIV-associated Opportunistic Pneumonias (IHOP) Study,
Published Date
- February 2012
Published In
Volume / Issue
- 72 / 2
Start / End Page
- 139 - 143
PubMed ID
- 22153850
Pubmed Central ID
- PMC3308345
Electronic International Standard Serial Number (EISSN)
- 1879-0070
Digital Object Identifier (DOI)
- 10.1016/j.diagmicrobio.2011.10.009
Language
- eng
Conference Location
- United States