Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia.

Journal Article (Journal Article)

Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)-infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed patients, but data on the prevalence of colonization are very limited in sub-Saharan Africa, where the majority of persons living with HIV reside. Our objective was to describe the epidemiology of P. jirovecii colonization among HIV-positive patients in a cross-sectional, hospital-based study of patients admitted with suspected pneumonia in Kampala, Uganda. P. jirovecii was detectable in bronchoalveolar lavage fluid from 7 (6%) of 124 consecutive patients with non-Pneumocystis pneumonia. Colonization was not associated with patient demographic or clinical information. This prevalence is substantially lower than in published studies in the developed world and suggests that there is a limited reservoir of organisms for clinical infections in this Ugandan population. These findings may partially explain the low incidence of Pneumocystis pneumonia in Uganda and other sub-Saharan African countries.

Full Text

Duke Authors

Cited Authors

  • Taylor, SM; Meshnick, SR; Worodria, W; Andama, A; Davis, JL; Cattamanchi, A; den Boon, S; Yoo, SD; Goodman, CD; Huang, L; International HIV-associated Opportunistic Pneumonias (IHOP) Study,

Published Date

  • February 2012

Published In

Volume / Issue

  • 72 / 2

Start / End Page

  • 139 - 143

PubMed ID

  • 22153850

Pubmed Central ID

  • PMC3308345

Electronic International Standard Serial Number (EISSN)

  • 1879-0070

Digital Object Identifier (DOI)

  • 10.1016/j.diagmicrobio.2011.10.009


  • eng

Conference Location

  • United States