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Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system--what is normal?

Publication ,  Journal Article
Ringe, KI; Husarik, DB; Gupta, RT; Boll, DT; Merkle, EM
Published in: Eur J Radiol
August 2011

OBJECTIVE: The purpose of this study was to determine transit times for excretion of Gd-EOB-DTPA into different segments of the hepatobiliary system in patients with normal liver function. METHODS: This retrospective study was IRB approved with a waiver of consent granted. 61 patients (39 female, 22 male, mean age 52.5 years) with normal liver and renal function who underwent contrast enhanced hepatic MRI after injection of 10 mL Gd-EOB-DTPA at 1.5T and 3T were included. Two readers evaluated all delayed images (3-20 min post contrast) for the presence of contrast agent in the intrahepatic bile ducts (IBD), the common bile duct (CBD), the gallbladder and the duodenum. A two-tailed, unpaired Student's t-test with p<0.05 deemed significant was used to determine whether transit times were affected by patient gender, age or body mass index. RESULTS: 20 min after contrast initiation, Gd-EOB-DTPA could be detected in the IBD and the CBD in all patients (100%); gallbladder reflux was visible in 53 (86.9%), duodenal excretion in 40 patients (65.5%), respectively. Mean transit times for contrast appearance in the various segments were as follows: IBD 12 min 13s; CBD 12 min 27 s; gallbladder 13 min 32s. Transit times were not significantly affected by patient gender, age or BMI. CONCLUSION: Within 20 min post contrast initiation, Gd-EOB-DTPA can be expected in the IBD and the CBD in patients with normal liver function. However, functional information about the sphincter Oddi complex can be ascertained only in about two thirds of these patients within this timeframe.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

August 2011

Volume

79

Issue

2

Start / End Page

201 / 205

Location

Ireland

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Function Tests
  • Liver Diseases
  • Humans
  • Gadolinium DTPA
  • Female
 

Citation

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ICMJE
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Ringe, K. I., Husarik, D. B., Gupta, R. T., Boll, D. T., & Merkle, E. M. (2011). Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system--what is normal? Eur J Radiol, 79(2), 201–205. https://doi.org/10.1016/j.ejrad.2010.03.008
Ringe, Kristina I., Daniela B. Husarik, Rajan T. Gupta, Daniel T. Boll, and Elmar M. Merkle. “Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system--what is normal?Eur J Radiol 79, no. 2 (August 2011): 201–5. https://doi.org/10.1016/j.ejrad.2010.03.008.
Ringe, Kristina I., et al. “Hepatobiliary transit times of gadoxetate disodium (Primovist®) for protocol optimization of comprehensive MR imaging of the biliary system--what is normal?Eur J Radiol, vol. 79, no. 2, Aug. 2011, pp. 201–05. Pubmed, doi:10.1016/j.ejrad.2010.03.008.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

August 2011

Volume

79

Issue

2

Start / End Page

201 / 205

Location

Ireland

Related Subject Headings

  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Function Tests
  • Liver Diseases
  • Humans
  • Gadolinium DTPA
  • Female