Skip to main content
Journal cover image

Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?

Publication ,  Journal Article
Bashir, MR; Gupta, RT; Davenport, MS; Allen, BC; Jaffe, TA; Ho, LM; Boll, DT; Merkle, EM
Published in: J Magn Reson Imaging
February 2013

PURPOSE: To evaluate the value of hepatobiliary phase imaging for detection and characterization of hepatocellular carcinoma (HCC) in liver MRI with Gd-EOB-DTPA, in a North American population. MATERIALS AND METHODS: One hundred MRI examinations performed with the intravenous injection of Gd-EOB-DTPA in patients with cirrhosis were reviewed retrospectively. Nodules were classified as HCC (n = 70), indeterminate (n = 33), or benign (n = 22). Five readers independently reviewed each examination with and without hepatobiliary phase images (HBP). Lesion conspicuity scores were compared between the two readings. Lesion detection, confidence scores, and receiver operating characteristic (ROC) analysis were compared. RESULTS: Lesion detection was slightly improved for all lesion types with the inclusion of the HBP, and was substantially higher for small HCCs (96.0% versus 85.3%). Mean confidence scores for the diagnosis of HCC increased for HCCs overall and each size category (P < 0.001). Diagnostic performance improved with the addition of the HBP (aggregate AROC 87.7% versus 80.0%, P < 0.01), and sensitivity for characterization improved (90.9% versus 78.3%, P < 0.01) while specificity was unchanged. CONCLUSION: Hepatobiliary phase imaging may improve small lesion detection (<1 cm) and characterization of lesions in general, in MRI of the cirrhotic liver with Gd-EOB-DTPA.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

February 2013

Volume

37

Issue

2

Start / End Page

398 / 406

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Risk Factors
  • Reproducibility of Results
  • Prevalence
  • Nuclear Medicine & Medical Imaging
  • North Carolina
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Cirrhosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bashir, M. R., Gupta, R. T., Davenport, M. S., Allen, B. C., Jaffe, T. A., Ho, L. M., … Merkle, E. M. (2013). Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis? J Magn Reson Imaging, 37(2), 398–406. https://doi.org/10.1002/jmri.23818
Bashir, Mustafa R., Rajan T. Gupta, Matthew S. Davenport, Brian C. Allen, Tracy A. Jaffe, Lisa M. Ho, Daniel T. Boll, and Elmar M. Merkle. “Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?J Magn Reson Imaging 37, no. 2 (February 2013): 398–406. https://doi.org/10.1002/jmri.23818.
Bashir MR, Gupta RT, Davenport MS, Allen BC, Jaffe TA, Ho LM, et al. Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis? J Magn Reson Imaging. 2013 Feb;37(2):398–406.
Bashir, Mustafa R., et al. “Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis?J Magn Reson Imaging, vol. 37, no. 2, Feb. 2013, pp. 398–406. Pubmed, doi:10.1002/jmri.23818.
Bashir MR, Gupta RT, Davenport MS, Allen BC, Jaffe TA, Ho LM, Boll DT, Merkle EM. Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis? J Magn Reson Imaging. 2013 Feb;37(2):398–406.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

February 2013

Volume

37

Issue

2

Start / End Page

398 / 406

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Risk Factors
  • Reproducibility of Results
  • Prevalence
  • Nuclear Medicine & Medical Imaging
  • North Carolina
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Cirrhosis