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Informing the dosing of interventions in randomized trials.

Publication ,  Journal Article
Voils, CI; Chang, Y; Crandell, J; Leeman, J; Sandelowski, M; Maciejewski, ML
Published in: Contemp Clin Trials
November 2012

Dosing is potentially the most important decision that must be made when building or refining behavioral interventions. In this paper, we propose standardized terminology and reporting of dosing information, which would inform intervention development, refinement for dissemination, and systematic reviews of dose-response relationships. Dosing of interventions may be characterized by duration, frequency, and amount. To illustrate the value of operationalizing these three parameters to evaluate dose-response relationships, 31 published reports of behavioral interventions to increase adherence to antiretroviral therapy (ART) were reviewed. The ART literature was characterized by under-reporting of dosing parameters, heterogeneity in dosing schedules, and heterogeneity in type of control group, which complicate analysis of dose-response relationships in systematic review and determination of the optimal dose for intervention dissemination. Improved reporting of the three dosing parameters and comparison of intended to actual delivery can inform the identification of the most effective intervention doses and the efficient implementation of efficacious interventions in clinical practice.

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Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

November 2012

Volume

33

Issue

6

Start / End Page

1225 / 1230

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Public Health
  • Humans
  • HIV Infections
  • General Clinical Medicine
  • Drug Administration Schedule
  • Drug Administration Routes
  • Dose-Response Relationship, Drug
  • Anti-Retroviral Agents
  • 42 Health sciences
 

Citation

APA
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ICMJE
MLA
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Voils, C. I., Chang, Y., Crandell, J., Leeman, J., Sandelowski, M., & Maciejewski, M. L. (2012). Informing the dosing of interventions in randomized trials. Contemp Clin Trials, 33(6), 1225–1230. https://doi.org/10.1016/j.cct.2012.07.011
Voils, Corrine I., Yunkyung Chang, Jamie Crandell, Jennifer Leeman, Margarete Sandelowski, and Matthew L. Maciejewski. “Informing the dosing of interventions in randomized trials.Contemp Clin Trials 33, no. 6 (November 2012): 1225–30. https://doi.org/10.1016/j.cct.2012.07.011.
Voils CI, Chang Y, Crandell J, Leeman J, Sandelowski M, Maciejewski ML. Informing the dosing of interventions in randomized trials. Contemp Clin Trials. 2012 Nov;33(6):1225–30.
Voils, Corrine I., et al. “Informing the dosing of interventions in randomized trials.Contemp Clin Trials, vol. 33, no. 6, Nov. 2012, pp. 1225–30. Pubmed, doi:10.1016/j.cct.2012.07.011.
Voils CI, Chang Y, Crandell J, Leeman J, Sandelowski M, Maciejewski ML. Informing the dosing of interventions in randomized trials. Contemp Clin Trials. 2012 Nov;33(6):1225–1230.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

November 2012

Volume

33

Issue

6

Start / End Page

1225 / 1230

Location

United States

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Public Health
  • Humans
  • HIV Infections
  • General Clinical Medicine
  • Drug Administration Schedule
  • Drug Administration Routes
  • Dose-Response Relationship, Drug
  • Anti-Retroviral Agents
  • 42 Health sciences