Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.
Journal Article (Journal Article)
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, accounting for approximately 7% of childhood cancers. Current therapies include nonspecific cytotoxic chemotherapy regimens, radiation therapy, and surgery; however, these multimodality strategies are unsuccessful in the majority of patients with high-risk disease. It is generally believed that these tumors represent arrested or aberrant skeletal muscle development, and, accordingly, developmental signaling pathways critical to myogenesis such as Notch, WNT, and Hedgehog may represent new therapeutic targets. In this paper, we summarize the current preclinical studies linking these embryonic pathways to rhabdomyosarcoma tumorigenesis and provide support for the investigation of targeted therapies in this embryonic cancer.
Full Text
Duke Authors
Cited Authors
- Belyea, B; Kephart, JG; Blum, J; Kirsch, DG; Linardic, CM
Published Date
- 2012
Published In
Volume / Issue
- 2012 /
Start / End Page
- 406239 -
PubMed ID
- 22619564
Pubmed Central ID
- PMC3350847
Electronic International Standard Serial Number (EISSN)
- 1369-1643
Digital Object Identifier (DOI)
- 10.1155/2012/406239
Language
- eng
Conference Location
- Egypt