Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.

Journal Article (Journal Article)

Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, accounting for approximately 7% of childhood cancers. Current therapies include nonspecific cytotoxic chemotherapy regimens, radiation therapy, and surgery; however, these multimodality strategies are unsuccessful in the majority of patients with high-risk disease. It is generally believed that these tumors represent arrested or aberrant skeletal muscle development, and, accordingly, developmental signaling pathways critical to myogenesis such as Notch, WNT, and Hedgehog may represent new therapeutic targets. In this paper, we summarize the current preclinical studies linking these embryonic pathways to rhabdomyosarcoma tumorigenesis and provide support for the investigation of targeted therapies in this embryonic cancer.

Full Text

Duke Authors

Cited Authors

  • Belyea, B; Kephart, JG; Blum, J; Kirsch, DG; Linardic, CM

Published Date

  • 2012

Published In

Volume / Issue

  • 2012 /

Start / End Page

  • 406239 -

PubMed ID

  • 22619564

Pubmed Central ID

  • PMC3350847

Electronic International Standard Serial Number (EISSN)

  • 1369-1643

Digital Object Identifier (DOI)

  • 10.1155/2012/406239


  • eng

Conference Location

  • Egypt