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Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists.

Publication ,  Journal Article
Wang, D; Bosch, W; Kirsch, DG; Al Lozi, R; El Naqa, I; Roberge, D; Finkelstein, SE; Petersen, I; Haddock, M; Chen, Y-LE; Saito, NG ...
Published in: Int J Radiat Oncol Biol Phys
December 1, 2011

PURPOSE: To evaluate variability in the definition of preoperative radiotherapy gross tumor volume (GTV) and clinical target volume (CTV) delineated by sarcoma radiation oncologists. METHODS AND MATERIALS: Extremity sarcoma planning CT images along with the corresponding diagnostic MRI from two patients were distributed to 10 Radiation Therapy Oncology Group sarcoma radiation oncologists with instructions to define GTV and CTV using standardized guidelines. The CT data with contours were then returned for central analysis. Contours representing statistically corrected 95% (V95) and 100% (V100) agreement were computed for each structure. RESULTS: For the GTV, the minimum, maximum, mean (SD) volumes (mL) were 674, 798, 752±35 for the lower extremity case and 383, 543, 447±46 for the upper extremity case. The volume (cc) of the union, V95 and V100 were 882, 761, and 752 for the lower, and 587, 461, and 455 for the upper extremity, respectively. The overall GTV agreement was judged to be almost perfect in both lower and upper extremity cases (kappa=0.9 [p<0.0001] and kappa=0.86 [p<0.0001]). For the CTV, the minimum, maximum, mean (SD) volumes (mL) were 1145, 1911, 1605±211 for the lower extremity case and 637, 1246, 1006±180 for the upper extremity case. The volume (cc) of the union, V95, and V100 were 2094, 1609, and 1593 for the lower, and 1533, 1020, and 965 for the upper extremity cases, respectively. The overall CTV agreement was judged to be almost perfect in the lower extremity case (kappa=0.85 [p<0.0001]) but only substantial in the upper extremity case (kappa=0.77 [p<0.0001]). CONCLUSIONS: Almost perfect agreement existed in the GTV of these two representative cases. There was no significant disagreement in the CTV of the lower extremity, but variation in the CTV of upper extremity was seen, perhaps related to the positional differences between the planning CT and the diagnostic MRI.

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Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

December 1, 2011

Volume

81

Issue

5

Start / End Page

e775 / e780

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Thigh
  • Soft Tissue Neoplasms
  • Sarcoma
  • Reproducibility of Results
  • Radiation Oncology
  • Preoperative Period
  • Oncology & Carcinogenesis
  • Observer Variation
 

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Wang, D., Bosch, W., Kirsch, D. G., Al Lozi, R., El Naqa, I., Roberge, D., … DeLaney, T. F. (2011). Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists. Int J Radiat Oncol Biol Phys, 81(5), e775–e780. https://doi.org/10.1016/j.ijrobp.2010.11.033
Wang, Dian, Walter Bosch, David G. Kirsch, Rawan Al Lozi, Issam El Naqa, David Roberge, Steven E. Finkelstein, et al. “Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists.Int J Radiat Oncol Biol Phys 81, no. 5 (December 1, 2011): e775–80. https://doi.org/10.1016/j.ijrobp.2010.11.033.
Wang, Dian, et al. “Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists.Int J Radiat Oncol Biol Phys, vol. 81, no. 5, Dec. 2011, pp. e775–80. Pubmed, doi:10.1016/j.ijrobp.2010.11.033.
Wang D, Bosch W, Kirsch DG, Al Lozi R, El Naqa I, Roberge D, Finkelstein SE, Petersen I, Haddock M, Chen Y-LE, Saito NG, Hitchcock YJ, Wolfson AH, DeLaney TF. Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists. Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):e775–e780.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

December 1, 2011

Volume

81

Issue

5

Start / End Page

e775 / e780

Location

United States

Related Subject Headings

  • Tumor Burden
  • Tomography, X-Ray Computed
  • Thigh
  • Soft Tissue Neoplasms
  • Sarcoma
  • Reproducibility of Results
  • Radiation Oncology
  • Preoperative Period
  • Oncology & Carcinogenesis
  • Observer Variation