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Are sulfonylureas passé?

Publication ,  Journal Article
Green, JB; Feinglos, MN
Published in: Curr Diab Rep
November 2006

Sulfonylureas and similarly acting rapid insulin secretagogues have long been available to manage type 2 diabetes. These agents have a well understood mechanism of action and are in large part well tolerated. However, sulfonylurea therapy is unlikely to sustain adequate long-term glycemic control and has potential side effects, including hypoglycemia and weight gain. Additional concerns exist regarding detrimental effects of certain sulfonylureas on ischemic preconditioning and cardiac outcomes. Fortunately, newer agents such as glimepiride appear less likely to adversely affect the myocardium. These agents can often be used successfully as one component of combination therapy for diabetes management.

Duke Scholars

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Published In

Curr Diab Rep

DOI

ISSN

1534-4827

Publication Date

November 2006

Volume

6

Issue

5

Start / End Page

373 / 377

Location

United States

Related Subject Headings

  • Weight Gain
  • Sulfonylurea Compounds
  • Hypoglycemic Agents
  • Humans
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1111 Nutrition and Dietetics
 

Citation

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Green, J. B., & Feinglos, M. N. (2006). Are sulfonylureas passé? Curr Diab Rep, 6(5), 373–377. https://doi.org/10.1007/s11892-006-0008-9
Green, Jennifer B., and Mark N. Feinglos. “Are sulfonylureas passé?Curr Diab Rep 6, no. 5 (November 2006): 373–77. https://doi.org/10.1007/s11892-006-0008-9.
Green JB, Feinglos MN. Are sulfonylureas passé? Curr Diab Rep. 2006 Nov;6(5):373–7.
Green, Jennifer B., and Mark N. Feinglos. “Are sulfonylureas passé?Curr Diab Rep, vol. 6, no. 5, Nov. 2006, pp. 373–77. Pubmed, doi:10.1007/s11892-006-0008-9.
Green JB, Feinglos MN. Are sulfonylureas passé? Curr Diab Rep. 2006 Nov;6(5):373–377.
Journal cover image

Published In

Curr Diab Rep

DOI

ISSN

1534-4827

Publication Date

November 2006

Volume

6

Issue

5

Start / End Page

373 / 377

Location

United States

Related Subject Headings

  • Weight Gain
  • Sulfonylurea Compounds
  • Hypoglycemic Agents
  • Humans
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • 3210 Nutrition and dietetics
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1111 Nutrition and Dietetics