Baseline predictors of A1C reduction in adults using sensor-augmented pump therapy or multiple daily injection therapy: the STAR 3 experience.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Baseline characteristics from the adult cohort of a randomized controlled trial comparing sensor-augmented pump (SAP) and multiple daily injection (MDI) therapy were analyzed for significant relationships with -0.5% A1C change at 1 year of therapy without incidence of severe hypoglycemia (defined as A1C benefit). METHODS: Baseline characteristics were compared with A1C benefit. Statistically significant predictors were analyzed further to determine appropriate cutpoints of relative A1C benefit. RESULTS: Baseline A1C ≥9.1%, age at randomization ≥36 years, and age at diabetes diagnosis of ≥17 years were associated with a greater SAP benefit relative to MDI than other cutpoints. CONCLUSIONS: People with type 1 diabetes who had a high A1C and who were older at diagnosis and older at randomization experienced the most benefit from SAP therapy.

Full Text

Duke Authors

Cited Authors

  • Buse, JB; Dailey, G; Ahmann, AA; Bergenstal, RM; Green, JB; Peoples, T; Tanenberg, RJ; Yang, Q

Published Date

  • June 2011

Published In

Volume / Issue

  • 13 / 6

Start / End Page

  • 601 - 606

PubMed ID

  • 21488717

Pubmed Central ID

  • PMC3101919

Electronic International Standard Serial Number (EISSN)

  • 1557-8593

Digital Object Identifier (DOI)

  • 10.1089/dia.2010.0225


  • eng

Conference Location

  • United States