Nicardipine infusion for postoperative hypertension after surgery of the head and neck.


Journal Article

The therapy of postoperative hypertension (POH) after head and neck surgery was evaluated in a prospective, randomized, double-blind trial. Nicardipine hydrochloride, a Ca channel-blocker for iv use, was compared with placebo. Patients were initially randomized to receive nicardipine infusion or placebo. Those not responding to placebo were given nicardipine infusion on an open basis. Hypertension was significantly better controlled in patients treated with nicardipine infusion compared with placebo (83% vs. 22%, p less than .002). Subsequently, six (86%) of seven of the placebo failures were successfully treated with nicardipine. There were no significant complications in either group. We conclude that the titratable infusion of nicardipine is an effective and safe method for the control of POH after surgery of the head and neck. Further studies are now warranted comparing nicardipine with other drugs currently used to treat this condition.

Full Text

Cited Authors

  • Halpern, NA; Sladen, RN; Goldberg, JS; Neely, C; Wood, M; Alicea, M; Krakoff, LR; Greenstein, R

Published Date

  • September 1990

Published In

Volume / Issue

  • 18 / 9

Start / End Page

  • 950 - 955

PubMed ID

  • 2203602

Pubmed Central ID

  • 2203602

International Standard Serial Number (ISSN)

  • 0090-3493

Digital Object Identifier (DOI)

  • 10.1097/00003246-199009000-00009


  • eng

Conference Location

  • United States