Early breast cancer therapy and cardiovascular injury.

Journal Article (Journal Article;Review)

Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy and proposes a new entity that we have labeled the "multiple-hit" hypothesis. The evidence that lifestyle modification, especially exercise therapy, may mitigate these adverse effects is also reviewed. These issues are of considerable practical importance for cardiovascular clinicians, as identification and intervention in those at high risk for cardiovascular complications may reduce a major cause of mortality in women with early breast cancer.

Full Text

Duke Authors

Cited Authors

  • Jones, LW; Haykowsky, MJ; Swartz, JJ; Douglas, PS; Mackey, JR

Published Date

  • October 9, 2007

Published In

Volume / Issue

  • 50 / 15

Start / End Page

  • 1435 - 1441

PubMed ID

  • 17919562

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2007.06.037


  • eng

Conference Location

  • United States