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Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer.

Publication ,  Journal Article
Jones, LW; Watson, D; Herndon, JE; Eves, ND; Haithcock, BE; Loewen, G; Kohman, L
Published in: Cancer
October 15, 2010

BACKGROUND: Identifying strong markers of prognosis is critical to optimize treatment and survival outcomes in patients with nonsmall cell lung cancer (NSCLC). The authors investigated the prognostic significance of preoperative cardiorespiratory fitness (peak oxygen consumption [VO(2peak)]) among operable candidates with NSCLC. METHODS: By using a prospective design, 398 patients with potentially resectable NSCLC enrolled in Cancer and Leukemia Group B 9238 were recruited between 1993 and 1998. Participants performed a cardiopulmonary exercise test to assess VO(2peak) and were observed until death or June 2008. Cox proportional models were used to estimate the risk of all-cause mortality according to cardiorespiratory fitness category defined by VO(2peak) tertiles (<0.96 of 0.96-1.29/>1.29 L/min⁻¹) with adjustment for age, sex, and performance status. RESULTS: Median follow-up was 30.8 months; 294 deaths were reported during this period. Compared with patients achieving a VO(2peak) <0.96 L/min⁻¹, the adjusted hazard ratio (HR) for all-cause mortality was 0.64 (95% confidence interval [CI], 0.46-0.88) for a VO(2peak) of 0.96 to 1.29 L/min⁻¹, and 0.56 (95% CI, 0.39-0.80) for a VO(2peak) of >1.29 L/min⁻¹) (P(trend) = .0037). The corresponding HRs for resected patients were 0.66 (95% CI, 0.46-0.95) and 0.59 (95% CI, 0.40-0.89) relative to the lowest VO(2peak) category (P(trend) = .0247), respectively. For nonresected patients, the HRs were 0.78 (95% CI, 0.34-1.79) and 0.39 (95% CI, 0.16-0.94) relative to the lowest category (P(trend) = .0278). CONCLUSIONS: VO(2peak) is a strong independent predictor of survival in NSCLC that may complement traditional markers of prognosis to improve risk stratification and prognostication.

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 15, 2010

Volume

116

Issue

20

Start / End Page

4825 / 4832

Location

United States

Related Subject Headings

  • Preoperative Period
  • Oxygen Consumption
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Exercise Test
  • Cause of Death
 

Citation

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Jones, L. W., Watson, D., Herndon, J. E., Eves, N. D., Haithcock, B. E., Loewen, G., & Kohman, L. (2010). Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer, 116(20), 4825–4832. https://doi.org/10.1002/cncr.25396
Jones, Lee W., Dorothy Watson, James E. Herndon, Neil D. Eves, Benjamin E. Haithcock, Gregory Loewen, and Leslie Kohman. “Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer.Cancer 116, no. 20 (October 15, 2010): 4825–32. https://doi.org/10.1002/cncr.25396.
Jones LW, Watson D, Herndon JE, Eves ND, Haithcock BE, Loewen G, et al. Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer. 2010 Oct 15;116(20):4825–32.
Jones, Lee W., et al. “Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer.Cancer, vol. 116, no. 20, Oct. 2010, pp. 4825–32. Pubmed, doi:10.1002/cncr.25396.
Jones LW, Watson D, Herndon JE, Eves ND, Haithcock BE, Loewen G, Kohman L. Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer. 2010 Oct 15;116(20):4825–4832.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

October 15, 2010

Volume

116

Issue

20

Start / End Page

4825 / 4832

Location

United States

Related Subject Headings

  • Preoperative Period
  • Oxygen Consumption
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Female
  • Exercise Test
  • Cause of Death