External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation.

Journal Article (Journal Article;Review)

Androgen deprivation plays a major role in the treatment of prostate cancer.Preclinical studies have shown that androgen deprivation provides both an independent cytotoxic effect and radiosensitization on prostate tumors. For men with non-metastatic prostate cancer, the addition of androgen deprivation to radiotherapy has been shown to improve survival for intermediate and high risk disease compared to radiation alone.This review discusses the clinical trial data regarding combination of androgen deprivation and radiation and provides recommendations for its use in men undergoing radiotherapy for localized prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Koontz, BF; Lee, WR

Published Date

  • October 2011

Published In

Volume / Issue

  • 64 / 8

Start / End Page

  • 858 - 864

PubMed ID

  • 22052767

Electronic International Standard Serial Number (EISSN)

  • 1576-8260


  • eng spa

Conference Location

  • Spain