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Direct measurement of lung motion using hyperpolarized helium-3 MR tagging.

Publication ,  Journal Article
Cai, J; Miller, GW; Altes, TA; Read, PW; Benedict, SH; de Lange, EE; Cates, GD; Brookeman, JR; Mugler, JP; Sheng, K
Published in: Int J Radiat Oncol Biol Phys
July 1, 2007

PURPOSE: To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP (3)He) magnetic resonance (MR) tagging technique. METHODS AND MATERIALS: Three healthy volunteers underwent MR tagging studies after inhalation of 1 L HP (3)He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed. RESULTS: The grids of tag lines in the HP (3)He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved. CONCLUSIONS: Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 1, 2007

Volume

68

Issue

3

Start / End Page

650 / 653

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Respiratory Mechanics
  • Radiopharmaceuticals
  • Oncology & Carcinogenesis
  • Movement
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Image Interpretation, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cai, J., Miller, G. W., Altes, T. A., Read, P. W., Benedict, S. H., de Lange, E. E., … Sheng, K. (2007). Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. Int J Radiat Oncol Biol Phys, 68(3), 650–653. https://doi.org/10.1016/j.ijrobp.2007.02.011
Cai, Jing, G Wilson Miller, Talissa A. Altes, Paul W. Read, Stanley H. Benedict, Eduard E. de Lange, Gordon D. Cates, James R. Brookeman, John P. Mugler, and Ke Sheng. “Direct measurement of lung motion using hyperpolarized helium-3 MR tagging.Int J Radiat Oncol Biol Phys 68, no. 3 (July 1, 2007): 650–53. https://doi.org/10.1016/j.ijrobp.2007.02.011.
Cai J, Miller GW, Altes TA, Read PW, Benedict SH, de Lange EE, et al. Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):650–3.
Cai, Jing, et al. “Direct measurement of lung motion using hyperpolarized helium-3 MR tagging.Int J Radiat Oncol Biol Phys, vol. 68, no. 3, July 2007, pp. 650–53. Pubmed, doi:10.1016/j.ijrobp.2007.02.011.
Cai J, Miller GW, Altes TA, Read PW, Benedict SH, de Lange EE, Cates GD, Brookeman JR, Mugler JP, Sheng K. Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):650–653.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 1, 2007

Volume

68

Issue

3

Start / End Page

650 / 653

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Respiratory Mechanics
  • Radiopharmaceuticals
  • Oncology & Carcinogenesis
  • Movement
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
  • Image Interpretation, Computer-Assisted