Direct measurement of lung motion using hyperpolarized helium-3 MR tagging.

Journal Article (Journal Article)

PURPOSE: To measure lung motion between end-inhalation and end-exhalation using a hyperpolarized helium-3 (HP (3)He) magnetic resonance (MR) tagging technique. METHODS AND MATERIALS: Three healthy volunteers underwent MR tagging studies after inhalation of 1 L HP (3)He gas diluted with nitrogen. Multiple-slice two-dimensional and volumetric three-dimensional MR tagged images of the lungs were obtained at end-inhalation and end-exhalation, and displacement vector maps were computed. RESULTS: The grids of tag lines in the HP (3)He MR images were well defined at end-inhalation and remained evident at end-exhalation. Displacement vector maps clearly demonstrated the regional lung motion and deformation that occurred during exhalation. Discontinuity and differences in motion pattern between two adjacent lung lobes were readily resolved. CONCLUSIONS: Hyperpolarized helium-3 MR tagging technique can be used for direct in vivo measurement of respiratory lung motion on a regional basis. This technique may lend new insights into the regional pulmonary biomechanics and thus provide valuable information for the deformable registration of lung.

Full Text

Duke Authors

Cited Authors

  • Cai, J; Miller, GW; Altes, TA; Read, PW; Benedict, SH; de Lange, EE; Cates, GD; Brookeman, JR; Mugler, JP; Sheng, K

Published Date

  • July 1, 2007

Published In

Volume / Issue

  • 68 / 3

Start / End Page

  • 650 - 653

PubMed ID

  • 17445997

Pubmed Central ID

  • PMC3658834

International Standard Serial Number (ISSN)

  • 0360-3016

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2007.02.011


  • eng

Conference Location

  • United States