Tracking brain motion during the cardiac cycle using spiral cine-DENSE MRI.

Published

Journal Article

Cardiac-synchronized brain motion is well documented, but the accurate measurement of such motion on the pixel-by-pixel basis has been hampered by the lack of proper imaging technique. In this article, the authors present the implementation of an autotracking spiral cine displacement-encoded stimulation echo (DENSE) magnetic resonance imaging (MRI) technique for the measurement of pulsatile brain motion during the cardiac cycle. Displacement-encoded dynamic MR images of three healthy volunteers were acquired throughout the cardiac cycle using the spiral cine-DENSE pulse sequence gated to the R wave of an electrocardiogram. Pixelwise Lagrangian displacement maps were computed, and 2D displacement as a function of time was determined for selected regions of interests. Different intracranial structures exhibited characteristic motion amplitude, direction, and pattern throughout the cardiac cycle. Time-resolved displacement curves revealed the pathway of pulsatile motion from brain stem to peripheral brain lobes. These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity.

Full Text

Duke Authors

Cited Authors

  • Zhong, X; Meyer, CH; Schlesinger, DJ; Sheehan, JP; Epstein, FH; Larner, JM; Benedict, SH; Read, PW; Sheng, K; Cai, J

Published Date

  • August 2009

Published In

Volume / Issue

  • 36 / 8

Start / End Page

  • 3413 - 3419

PubMed ID

  • 19746774

Pubmed Central ID

  • 19746774

Electronic International Standard Serial Number (EISSN)

  • 2473-4209

International Standard Serial Number (ISSN)

  • 0094-2405

Digital Object Identifier (DOI)

  • 10.1118/1.3157109

Language

  • eng