Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathing.

Journal Article (Journal Article)

PURPOSE: To develop a dynamic magnetic resonance imaging (MRI) tagging technique using hyperpolarized helium-3 (HP He-3) to track lung motion. METHODS AND MATERIALS: An accelerated non-Cartesian k-space trajectory was used to gain acquisition speed, at the cost of introducing image artifacts, providing a viable strategy for obtaining whole-lung coverage with adequate temporal resolution. Multiple-slice two-dimensional dynamic images of the lung were obtained in three healthy subjects after inhaling He-3 gas polarized to 35%-40%. Displacement, strain, and ventilation maps were computed from the observed motion of the grid peaks. RESULTS: Both temporal and spatial variations of pulmonary mechanics were observed in normal subjects, including shear motion between different lobes of the same lung. CONCLUSION: These initial results suggest that dynamic imaging of grid-tagged hyperpolarized magnetization may potentially be a powerful tool for observing and quantifying pulmonary biomechanics on a regional basis and for assessing, validating, and improving lung deformable image registration algorithms.

Full Text

Duke Authors

Cited Authors

  • Cai, J; Sheng, K; Benedict, SH; Read, PW; Larner, JM; Mugler, JP; de Lange, EE; Cates, GD; Miller, GW

Published Date

  • September 1, 2009

Published In

Volume / Issue

  • 75 / 1

Start / End Page

  • 276 - 284

PubMed ID

  • 19540059

Pubmed Central ID

  • PMC2752969

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2009.03.051


  • eng

Conference Location

  • United States