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New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.

Publication ,  Journal Article
Walker, JKL; Penn, RB; Hanania, NA; Dickey, BF; Bond, RA
Published in: British journal of pharmacology
May 2011

In the last two decades several significant changes have been proposed in the receptor theory that describes how ligands can interact with G protein-coupled receptors (GPCRs). Here we briefly summarize the evolution of receptor theory and detail recent prominent advances. These include: (i) the existence of spontaneously active GPCRs that are capable of signalling even though they are unoccupied by any ligand; (ii) the discovery of ligands that can inactivate these spontaneously active receptors; (iii) the notion that a ligand may simultaneously activate more than one GPCR signalling pathway; and (iv) the notion that certain ligands may be able to preferentially direct receptor signalling to a specific pathway. Because the data supporting these receptor theory ideas are derived primarily from studies using artificial expression systems, the physiological relevance of these new paradigms remains in question. As a potential example of how these new perspectives in receptor theory relate to drug actions and clinical outcomes, we discuss their relevance to the recent controversy regarding the chronic use of β(2) -adrenoceptor agonists in the treatment of asthma.

Duke Scholars

Published In

British journal of pharmacology

DOI

EISSN

1476-5381

ISSN

0007-1188

Publication Date

May 2011

Volume

163

Issue

1

Start / End Page

18 / 28

Related Subject Headings

  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Receptors, Adrenergic, beta-2
  • Pharmacology & Pharmacy
  • Ligands
  • Humans
  • Asthma
  • Animals
  • Adrenergic beta-2 Receptor Agonists
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Walker, J. K. L., Penn, R. B., Hanania, N. A., Dickey, B. F., & Bond, R. A. (2011). New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. British Journal of Pharmacology, 163(1), 18–28. https://doi.org/10.1111/j.1476-5381.2010.01178.x
Walker, J. K. L., R. B. Penn, N. A. Hanania, B. F. Dickey, and R. A. Bond. “New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.British Journal of Pharmacology 163, no. 1 (May 2011): 18–28. https://doi.org/10.1111/j.1476-5381.2010.01178.x.
Walker JKL, Penn RB, Hanania NA, Dickey BF, Bond RA. New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. British journal of pharmacology. 2011 May;163(1):18–28.
Walker, J. K. L., et al. “New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma.British Journal of Pharmacology, vol. 163, no. 1, May 2011, pp. 18–28. Epmc, doi:10.1111/j.1476-5381.2010.01178.x.
Walker JKL, Penn RB, Hanania NA, Dickey BF, Bond RA. New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. British journal of pharmacology. 2011 May;163(1):18–28.
Journal cover image

Published In

British journal of pharmacology

DOI

EISSN

1476-5381

ISSN

0007-1188

Publication Date

May 2011

Volume

163

Issue

1

Start / End Page

18 / 28

Related Subject Headings

  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Receptors, Adrenergic, beta-2
  • Pharmacology & Pharmacy
  • Ligands
  • Humans
  • Asthma
  • Animals
  • Adrenergic beta-2 Receptor Agonists
  • 3214 Pharmacology and pharmaceutical sciences