Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.

Published

Journal Article

Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the enteric virome. We identified at least 32 previously undescribed enteric viruses during pathogenic SIV infection and confirmed their presence by using viral culture and PCR testing. We detected unsuspected mucosal adenovirus infection associated with enteritis as well as parvovirus viremia in animals with advanced AIDS, indicating the pathogenic potential of SIV-associated expansion of the enteric virome. No association between pathogenic SIV infection and the family-level taxonomy of enteric bacteria was detected. Thus, enteric viral infections may contribute to AIDS enteropathy and disease progression. These findings underline the importance of metagenomic analysis of the virome for understanding AIDS pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Handley, SA; Thackray, LB; Zhao, G; Presti, R; Miller, AD; Droit, L; Abbink, P; Maxfield, LF; Kambal, A; Duan, E; Stanley, K; Kramer, J; Macri, SC; Permar, SR; Schmitz, JE; Mansfield, K; Brenchley, JM; Veazey, RS; Stappenbeck, TS; Wang, D; Barouch, DH; Virgin, HW

Published Date

  • October 12, 2012

Published In

Volume / Issue

  • 151 / 2

Start / End Page

  • 253 - 266

PubMed ID

  • 23063120

Pubmed Central ID

  • 23063120

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2012.09.024

Language

  • eng

Conference Location

  • United States