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Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys.

Publication ,  Journal Article
Schmitz, JE; Ma, Z-M; Hagan, EA; Wilks, AB; Furr, KL; Linde, CH; Zahn, RC; Brenchley, JM; Miller, CJ; Permar, SR
Published in: J Virol
October 2012

Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

October 2012

Volume

86

Issue

20

Start / End Page

11380 / 11385

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Messenger
  • Immunologic Memory
  • Gastrointestinal Tract
  • Chlorocebus aethiops
 

Citation

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Schmitz, J. E., Ma, Z.-M., Hagan, E. A., Wilks, A. B., Furr, K. L., Linde, C. H., … Permar, S. R. (2012). Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys. J Virol, 86(20), 11380–11385. https://doi.org/10.1128/JVI.01556-12
Schmitz, Joern E., Zhong-Min Ma, Emily A. Hagan, Andrew B. Wilks, Kathryn L. Furr, Caitlyn H. Linde, Roland C. Zahn, Jason M. Brenchley, Christopher J. Miller, and Sallie R. Permar. “Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys.J Virol 86, no. 20 (October 2012): 11380–85. https://doi.org/10.1128/JVI.01556-12.
Schmitz JE, Ma Z-M, Hagan EA, Wilks AB, Furr KL, Linde CH, Zahn RC, Brenchley JM, Miller CJ, Permar SR. Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys. J Virol. 2012 Oct;86(20):11380–11385.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

October 2012

Volume

86

Issue

20

Start / End Page

11380 / 11385

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Viral Load
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Messenger
  • Immunologic Memory
  • Gastrointestinal Tract
  • Chlorocebus aethiops