A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.


Journal Article

Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.

Full Text

Duke Authors

Cited Authors

  • Doria-Rose, NA; Georgiev, I; O'Dell, S; Chuang, G-Y; Staupe, RP; McLellan, JS; Gorman, J; Pancera, M; Bonsignori, M; Haynes, BF; Burton, DR; Koff, WC; Kwong, PD; Mascola, JR

Published Date

  • August 2012

Published In

Volume / Issue

  • 86 / 15

Start / End Page

  • 8319 - 8323

PubMed ID

  • 22623764

Pubmed Central ID

  • 22623764

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.00696-12


  • eng

Conference Location

  • United States