A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies.
Published
Journal Article
Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.
Full Text
Duke Authors
Cited Authors
- Doria-Rose, NA; Georgiev, I; O'Dell, S; Chuang, G-Y; Staupe, RP; McLellan, JS; Gorman, J; Pancera, M; Bonsignori, M; Haynes, BF; Burton, DR; Koff, WC; Kwong, PD; Mascola, JR
Published Date
- August 2012
Published In
Volume / Issue
- 86 / 15
Start / End Page
- 8319 - 8323
PubMed ID
- 22623764
Pubmed Central ID
- 22623764
Electronic International Standard Serial Number (EISSN)
- 1098-5514
Digital Object Identifier (DOI)
- 10.1128/JVI.00696-12
Language
- eng
Conference Location
- United States