Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.
Published
Journal Article
Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.
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Duke Authors
- Bonsignori, Mattia
- Crump, John Andrew
- Haynes, Barton Ford
- Liao, Hua-Xin
- Montefiori, David Charles
- Tomaras, Georgia Doris
Cited Authors
- Bonsignori, M; Montefiori, DC; Wu, X; Chen, X; Hwang, K-K; Tsao, C-Y; Kozink, DM; Parks, RJ; Tomaras, GD; Crump, JA; Kapiga, SH; Sam, NE; Kwong, PD; Kepler, TB; Liao, H-X; Mascola, JR; Haynes, BF
Published Date
- April 2012
Published In
Volume / Issue
- 86 / 8
Start / End Page
- 4688 - 4692
PubMed ID
- 22301150
Pubmed Central ID
- 22301150
Electronic International Standard Serial Number (EISSN)
- 1098-5514
Digital Object Identifier (DOI)
- 10.1128/JVI.07163-11
Language
- eng
Conference Location
- United States