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Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

Publication ,  Journal Article
Bonsignori, M; Montefiori, DC; Wu, X; Chen, X; Hwang, K-K; Tsao, C-Y; Kozink, DM; Parks, RJ; Tomaras, GD; Crump, JA; Kapiga, SH; Sam, NE ...
Published in: J Virol
April 2012

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

April 2012

Volume

86

Issue

8

Start / End Page

4688 / 4692

Location

United States

Related Subject Headings

  • Virology
  • Phylogeny
  • Neutralization Tests
  • Immunoglobulin Variable Region
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Epitopes
 

Citation

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Bonsignori, M., Montefiori, D. C., Wu, X., Chen, X., Hwang, K.-K., Tsao, C.-Y., … Haynes, B. F. (2012). Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol, 86(8), 4688–4692. https://doi.org/10.1128/JVI.07163-11
Bonsignori, Mattia, David C. Montefiori, Xueling Wu, Xi Chen, Kwan-Ki Hwang, Chun-Yen Tsao, Daniel M. Kozink, et al. “Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.J Virol 86, no. 8 (April 2012): 4688–92. https://doi.org/10.1128/JVI.07163-11.
Bonsignori M, Montefiori DC, Wu X, Chen X, Hwang K-K, Tsao C-Y, et al. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol. 2012 Apr;86(8):4688–92.
Bonsignori, Mattia, et al. “Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.J Virol, vol. 86, no. 8, Apr. 2012, pp. 4688–92. Pubmed, doi:10.1128/JVI.07163-11.
Bonsignori M, Montefiori DC, Wu X, Chen X, Hwang K-K, Tsao C-Y, Kozink DM, Parks RJ, Tomaras GD, Crump JA, Kapiga SH, Sam NE, Kwong PD, Kepler TB, Liao H-X, Mascola JR, Haynes BF. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol. 2012 Apr;86(8):4688–4692.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

April 2012

Volume

86

Issue

8

Start / End Page

4688 / 4692

Location

United States

Related Subject Headings

  • Virology
  • Phylogeny
  • Neutralization Tests
  • Immunoglobulin Variable Region
  • Humans
  • HIV-1
  • HIV Infections
  • HIV Envelope Protein gp120
  • HIV Antibodies
  • Epitopes