Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains.


Journal Article

Comparisons were made with age on phagocytosis, chemotaxis, and esterase staining of autoimmune-resistant and autoimmune-susceptible mouse strains. Consistent increases of each parameter occurred with age. Autoimmune strains generally showed less change with age than autoimmune-resistant mice and the changes with aging were less consistent. These findings suggest that phagocytic cells may play an important role in the autoimmunities or the lymphoproliferative processes that occur in autoimmune-prone mice and/or in loss of immune function with aging.

Full Text

Duke Authors

Cited Authors

  • Wustrow, TP; Denny, TN; Fernandes, G; Good, RA

Published Date

  • February 1, 1984

Published In

Volume / Issue

  • 83 / 2

Start / End Page

  • 321 - 329

PubMed ID

  • 6692481

Pubmed Central ID

  • 6692481

International Standard Serial Number (ISSN)

  • 0008-8749

Digital Object Identifier (DOI)

  • 10.1016/0008-8749(84)90311-3


  • eng

Conference Location

  • Netherlands