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HIV-2-associated AIDS in the United States. The first case.

Publication ,  Journal Article
Kloser, PC; Mangia, AJ; Leonard, J; Lombardo, JM; Michaels, J; Denny, TN; Sharer, L; Sathe, S; Weiss, SH; Schable, C
Published in: Arch Intern Med
August 1989

A 41-year-old woman from the Cape Verde Islands, Africa, who had been residing in the United States for 11 months was found to have human immunodeficiency virus type 2 (HIV-2)-associated acquired immunodeficiency syndrome (AIDS). Antibody to HIV-2 was found by enzyme immunoassay and was verified by radioimmunoprecipitation. The patient was being treated for pulmonary tuberculosis at the time of her admission to our institution. Further laboratory and clinical evaluation at our facility revealed depressed CD4 lymphocytes, oral candidiasis, and cryptococcal meningitis with indeterminate results on serologic testing for HIV type 1 (HIV-1). The biopsy specimen of a lesion in the right occipital lobe of the brain documented Toxoplasma gondii, indicating a clinical diagnosis of AIDS. To our knowledge, our study presents the first known patient with HIV-2-associated AIDS in the United States. Our patient provides further evidence that HIV-2 causes severe immunodeficiency and opportunistic infection. The condition should be suspected in the face of normal or repeatedly equivocal HIV-1 antibody test results in the presence of clinically documented AIDS.

Duke Scholars

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

August 1989

Volume

149

Issue

8

Start / End Page

1875 / 1877

Location

United States

Related Subject Headings

  • United States
  • Tuberculosis, Pulmonary
  • Toxoplasmosis
  • Humans
  • HIV-2
  • HIV Antibodies
  • General & Internal Medicine
  • Female
  • Brain Diseases
  • Atlantic Islands
 

Citation

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Kloser, P. C., Mangia, A. J., Leonard, J., Lombardo, J. M., Michaels, J., Denny, T. N., … Schable, C. (1989). HIV-2-associated AIDS in the United States. The first case. Arch Intern Med, 149(8), 1875–1877.
Kloser, P. C., A. J. Mangia, J. Leonard, J. M. Lombardo, J. Michaels, T. N. Denny, L. Sharer, S. Sathe, S. H. Weiss, and C. Schable. “HIV-2-associated AIDS in the United States. The first case.Arch Intern Med 149, no. 8 (August 1989): 1875–77.
Kloser PC, Mangia AJ, Leonard J, Lombardo JM, Michaels J, Denny TN, et al. HIV-2-associated AIDS in the United States. The first case. Arch Intern Med. 1989 Aug;149(8):1875–7.
Kloser, P. C., et al. “HIV-2-associated AIDS in the United States. The first case.Arch Intern Med, vol. 149, no. 8, Aug. 1989, pp. 1875–77.
Kloser PC, Mangia AJ, Leonard J, Lombardo JM, Michaels J, Denny TN, Sharer L, Sathe S, Weiss SH, Schable C. HIV-2-associated AIDS in the United States. The first case. Arch Intern Med. 1989 Aug;149(8):1875–1877.

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

August 1989

Volume

149

Issue

8

Start / End Page

1875 / 1877

Location

United States

Related Subject Headings

  • United States
  • Tuberculosis, Pulmonary
  • Toxoplasmosis
  • Humans
  • HIV-2
  • HIV Antibodies
  • General & Internal Medicine
  • Female
  • Brain Diseases
  • Atlantic Islands