HIV-2-associated AIDS in the United States. The first case.

Journal Article (Journal Article)

A 41-year-old woman from the Cape Verde Islands, Africa, who had been residing in the United States for 11 months was found to have human immunodeficiency virus type 2 (HIV-2)-associated acquired immunodeficiency syndrome (AIDS). Antibody to HIV-2 was found by enzyme immunoassay and was verified by radioimmunoprecipitation. The patient was being treated for pulmonary tuberculosis at the time of her admission to our institution. Further laboratory and clinical evaluation at our facility revealed depressed CD4 lymphocytes, oral candidiasis, and cryptococcal meningitis with indeterminate results on serologic testing for HIV type 1 (HIV-1). The biopsy specimen of a lesion in the right occipital lobe of the brain documented Toxoplasma gondii, indicating a clinical diagnosis of AIDS. To our knowledge, our study presents the first known patient with HIV-2-associated AIDS in the United States. Our patient provides further evidence that HIV-2 causes severe immunodeficiency and opportunistic infection. The condition should be suspected in the face of normal or repeatedly equivocal HIV-1 antibody test results in the presence of clinically documented AIDS.

Full Text

Duke Authors

Cited Authors

  • Kloser, PC; Mangia, AJ; Leonard, J; Lombardo, JM; Michaels, J; Denny, TN; Sharer, L; Sathe, S; Weiss, SH; Schable, C

Published Date

  • August 1, 1989

Published In

Volume / Issue

  • 149 / 8

Start / End Page

  • 1875 - 1877

PubMed ID

  • 2764658

Pubmed Central ID

  • 2764658

International Standard Serial Number (ISSN)

  • 0003-9926


  • eng

Conference Location

  • United States