Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.

Published

Journal Article

Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. The incorporation of luminescent molecules into NPs adds optical imaging and sensing capability to these vectors. Here we report on the synthesis of dual-emissive, pegylated NPs with "stealth"-like properties, delivered intravenously (IV), for the study of tumor accumulation. The NPs were created by means of stereocomplexation using a methoxy-terminated polyethylene glycol and poly(D-lactide) (mPEG-PDLA) block copolymer combined with iodide-substituted difluoroboron dibenzoylmethane-poly(L-lactide) (BF2dbm(I)PLLA). Boron nanoparticles (BNPs) were fabricated in two different solvent compositions to study the effects on BNP size distribution. The physical and photoluminescent properties of the BNPs were studied in vitro over time to determine stability. Finally, preliminary in vivo results show that stereocomplexed BNPs injected IV are taken up by tumors, an important prerequisite to their use as hypoxia imaging agents in preclinical studies.

Full Text

Duke Authors

Cited Authors

  • Kersey, FR; Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL

Published Date

  • September 28, 2010

Published In

Volume / Issue

  • 4 / 9

Start / End Page

  • 4989 - 4996

PubMed ID

  • 20704337

Pubmed Central ID

  • 20704337

Electronic International Standard Serial Number (EISSN)

  • 1936-086X

Digital Object Identifier (DOI)

  • 10.1021/nn901873t

Language

  • eng

Conference Location

  • United States