Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

Journal Article (Journal Article;Review)

Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise - oncology' has broadened in scope to investigate whether the benefits extend beyond symptom control to modulate cancer-specific outcomes (i.e., cancer progression and metastasis). Here we review the extant epidemiological evidence examining the association between exercise behavior, functional capacity/exercise capacity, and cancer-specific recurrence and mortality as well as all-cause mortality individuals following a cancer diagnosis. We also evaluate evidence from clinical studies investigating the effects of structured exercise on blood-based biomarkers associated with cancer progression/metastasis as well findings from preclinical investigations examining the effects and molecular mechanisms of exercise in mouse models of cancer. Current gaps in knowledge are also discussed.

Full Text

Duke Authors

Cited Authors

  • Betof, AS; Dewhirst, MW; Jones, LW

Published Date

  • March 2013

Published In

Volume / Issue

  • 30 Suppl / 0

Start / End Page

  • S75 - S87

PubMed ID

  • 22610066

Pubmed Central ID

  • PMC3638811

Electronic International Standard Serial Number (EISSN)

  • 1090-2139

Digital Object Identifier (DOI)

  • 10.1016/j.bbi.2012.05.001


  • eng

Conference Location

  • Netherlands