Anxiety-like behaviors in mice lacking GIT2.

Journal Article (Journal Article)

G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.

Full Text

Duke Authors

Cited Authors

  • Schmalzigaug, R; Rodriguiz, RM; Phillips, LE; Davidson, CE; Wetsel, WC; Premont, RT

Published Date

  • February 20, 2009

Published In

Volume / Issue

  • 451 / 2

Start / End Page

  • 156 - 161

PubMed ID

  • 19114090

Pubmed Central ID

  • PMC2648396

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/j.neulet.2008.12.034


  • eng

Conference Location

  • Ireland