Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.
Journal Article (Journal Article)
Using isoenzyme-specific antisera, protein kinase C (PKC) alpha and PKC delta were detected in total liver homogenate and in isolated nuclei. PKC beta I, beta II, epsilon, epsilon', and zeta were not detected. During liver regeneration, nuclear PKC alpha levels decreased while PKC delta levels increased. These studies demonstrate, for the first time, the presence of a calcium-independent PKC isoenzyme in liver nuclei and suggest that PKC alpha and PKC delta may have different roles in liver regeneration and cell proliferation.
Full Text
Duke Authors
Cited Authors
- Alessenko, A; Khan, WA; Wetsel, WC; Hannun, YA
Published Date
- February 14, 1992
Published In
Volume / Issue
- 182 / 3
Start / End Page
- 1333 - 1339
PubMed ID
- 1540177
International Standard Serial Number (ISSN)
- 0006-291X
Digital Object Identifier (DOI)
- 10.1016/0006-291x(92)91879-u
Language
- eng
Conference Location
- United States