Effect of hypophysectomy on somatostatin-14 and somatostatin-28 biosynthesis in the rat hypothalamus.

Journal Article (Journal Article)

The in vivo incorporation of [35S]cysteine into hypothalamic somatostatin-28 was found to be substantially below normal in hypophysectomized rats. A smaller reduction in label incorporation into arginine vasopressin was also observed, while incorporation into acid-precipitable protein was normal. The diminution in somatostatin biosynthesis presumably reflects the absence of pituitary growth hormone secretion, while that in vasopressin synthesis may reflect the loss or disruption of vasopressin-producing cells.

Full Text

Duke Authors

Cited Authors

  • Wetsel, WC; Fernstrom, JD

Published Date

  • April 9, 1986

Published In

Volume / Issue

  • 370 / 2

Start / End Page

  • 315 - 320

PubMed ID

  • 2871892

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)90486-5


  • eng

Conference Location

  • Netherlands