Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet.
Griffin, TM; Fermor, B; Huebner, JL; Kraus, VB; Rodriguiz, RM; Wetsel, WC; Cao, L; Setton, LA; Guilak, F
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