New roles of carboxypeptidase E in endocrine and neural function and cancer.

Journal Article (Review)

Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors to generate enkephalin. Since then, CPE has been shown to be a multifunctional protein that subserves many essential nonenzymatic roles in the endocrine and nervous systems. Here, we review the phylogeny, structure, and function of CPE in hormone and neuropeptide sorting and vesicle transport for secretion, alternative splicing of the CPE transcript, and single nucleotide polymorphisms in humans. With this and the analysis of mutant and knockout mice, the data collectively support important roles for CPE in the modulation of metabolic and glucose homeostasis, bone remodeling, obesity, fertility, neuroprotection, stress, sexual behavior, mood and emotional responses, learning, and memory. Recently, a splice variant form of CPE has been found to be an inducer of tumor growth and metastasis and a prognostic biomarker for metastasis in endocrine and nonendocrine tumors.

Full Text

Duke Authors

Cited Authors

  • Cawley, NX; Wetsel, WC; Murthy, SRK; Park, JJ; Pacak, K; Loh, YP

Published Date

  • April 2012

Published In

Volume / Issue

  • 33 / 2

Start / End Page

  • 216 - 253

PubMed ID

  • 22402194

Pubmed Central ID

  • 22402194

Electronic International Standard Serial Number (EISSN)

  • 1945-7189

Digital Object Identifier (DOI)

  • 10.1210/er.2011-1039


  • eng

Conference Location

  • United States