Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.

Journal Article

The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, with an EC50 twofold higher than control fibroblasts. Furthermore, we observed that such defective regulation of the amyloid precursor secretion can possibly be correlated to a specific defect in protein kinase C alpha in fibroblasts from Alzheimer patients.

Full Text

Duke Authors

Cited Authors

  • Bergamaschi, S; Binetti, G; Govoni, S; Wetsel, WC; Battaini, F; Trabucchi, M; Bianchetti, A; Racchi, M

Published Date

  • December 1, 1995

Published In

Volume / Issue

  • 201 / 1

Start / End Page

  • 1 - 5

PubMed ID

  • 8830300

International Standard Serial Number (ISSN)

  • 0304-3940

Language

  • eng

Conference Location

  • Ireland