Skip to main content

WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.

Publication ,  Journal Article
Carlson, BR; Lloyd, KE; Kruszewski, A; Kim, I-H; Rodriguiz, RM; Heindel, C; Faytell, M; Dudek, SM; Wetsel, WC; Soderling, SH
Published in: J Neurosci
February 16, 2011

The WAVE-associated Rac GAP, WRP, is thought to regulate key aspects of synapse development and function and may be linked to mental retardation in humans. WRP contains a newly described inverse F-BAR (IF-BAR) domain of unknown function. Our studies show that this domain senses/facilitates outward protrusions analogous to filopodia and that the molecular basis for this is likely explained by a convex lipid-binding surface on the WRP IF-BAR domain. In dendrites the IF-BAR domain of WRP forms a bud on the shaft from which precursors to spines emerge. Loss of WRP in vivo and in vitro results in reduced density of spines. In vivo this is primarily a loss of mushroom-shaped spines. Developmentally, WRP function is critical at the onset of spinogenesis, when dendritic filopodia are prevalent. Finally, because WRP is implicated in mental retardation, behaviors of WRP heterozygous and null mice have been evaluated. Results from these studies confirm that loss of WRP is linked to impaired learning and memory.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

February 16, 2011

Volume

31

Issue

7

Start / End Page

2447 / 2460

Location

United States

Related Subject Headings

  • Sensation
  • Protein Interaction Domains and Motifs
  • Phosphatidylinositols
  • Neuropsychological Tests
  • Neurons
  • Neurology & Neurosurgery
  • Models, Chemical
  • Microscopy, Electron, Scanning
  • Mice, Knockout
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carlson, B. R., Lloyd, K. E., Kruszewski, A., Kim, I.-H., Rodriguiz, R. M., Heindel, C., … Soderling, S. H. (2011). WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci, 31(7), 2447–2460. https://doi.org/10.1523/JNEUROSCI.4433-10.2011
Carlson, Benjamin R., Krissey E. Lloyd, Allison Kruszewski, Il-Hwan Kim, Ramona M. Rodriguiz, Clifford Heindel, Marika Faytell, Serena M. Dudek, William C. Wetsel, and Scott H. Soderling. “WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.J Neurosci 31, no. 7 (February 16, 2011): 2447–60. https://doi.org/10.1523/JNEUROSCI.4433-10.2011.
Carlson BR, Lloyd KE, Kruszewski A, Kim I-H, Rodriguiz RM, Heindel C, et al. WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci. 2011 Feb 16;31(7):2447–60.
Carlson, Benjamin R., et al. “WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.J Neurosci, vol. 31, no. 7, Feb. 2011, pp. 2447–60. Pubmed, doi:10.1523/JNEUROSCI.4433-10.2011.
Carlson BR, Lloyd KE, Kruszewski A, Kim I-H, Rodriguiz RM, Heindel C, Faytell M, Dudek SM, Wetsel WC, Soderling SH. WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci. 2011 Feb 16;31(7):2447–2460.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

February 16, 2011

Volume

31

Issue

7

Start / End Page

2447 / 2460

Location

United States

Related Subject Headings

  • Sensation
  • Protein Interaction Domains and Motifs
  • Phosphatidylinositols
  • Neuropsychological Tests
  • Neurons
  • Neurology & Neurosurgery
  • Models, Chemical
  • Microscopy, Electron, Scanning
  • Mice, Knockout
  • Mice