A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.

Journal Article (Journal Article)

This retrospective cohort study conducted at the Durham Veterans Affairs Medical Center evaluated the effectiveness and safety of lipid-lowering therapy (LLT) in a HIV-infected population as compared with a general population with hyperlipidaemia. Fifty-three HIV-infected subjects who developed dyslipidaemia and 53 age-matched non-HIV-infected subjects receiving LLT were selected. Efficacy of LLT was assessed after three and six months. Non-HIV-infected subjects were more likely to achieve total cholesterol (TC) goals at three and six months (P = 0.045, P = 0.005) and triglyceride (TG) goals at six months (P = 0.017). Less than 45% of HIV-infected subjects met National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) goals at three or six months. While non-HIV-infected subjects were more likely to achieve TC and TG goals than HIV-infected subjects, overall achievement of NCEP III goals was poor. This result was likely due to treatment with inappropriately low doses of statins.

Full Text

Duke Authors

Cited Authors

  • Townsend, ML; Hollowell, SB; Bhalodia, J; Wilson, KH; Kaye, KS; Johnson, MD

Published Date

  • December 2007

Published In

Volume / Issue

  • 18 / 12

Start / End Page

  • 851 - 855

PubMed ID

  • 18073021

International Standard Serial Number (ISSN)

  • 0956-4624

Digital Object Identifier (DOI)

  • 10.1258/095646207782716974


  • eng

Conference Location

  • England