Luteolytic and abortifacient effects of serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha in early pregnancy.
Published
Journal Article
Pregnancy was successfully terminated in 8 of 9 patients 5 to 6 weeks after the last menstrual period by serial intramuscular injections of 15(S)-15-methyl-prostaglandin F2alpha (15-ME-PGF2alpha). In one patient the treatment induced vaginal bleeding and a drop in hormone levels, but the patient did not completely abort and the uterus had to be evacuated. Serial intramuscular injections of 15-ME-PGF2alpha appeared to have some luteolytic effect, resulting in a significant drop in progesterone and estradiol levels. However, it is uncertain if the luteolytic effect of the prostaglandin was the precipitating factor in the abortion since the administration of 15-ME-PFG2alpha was accompanied by strong uterine activity which played a role in the abortion.
Full Text
Duke Authors
Cited Authors
- Lauersen, NH; Wilson, KH
Published Date
- February 15, 1976
Published In
Volume / Issue
- 124 / 4
Start / End Page
- 425 - 429
PubMed ID
- 1251863
Pubmed Central ID
- 1251863
International Standard Serial Number (ISSN)
- 0002-9378
Digital Object Identifier (DOI)
- 10.1016/0002-9378(76)90106-x
Language
- eng
Conference Location
- United States