Phylogeny of the Whipple's-disease-associated bacterium.

Journal Article (Journal Article)

Efforts to culture and identify the intracellular bacteria associated with Whipple's disease have been unsuccessful. Nucleotide sequencing and amplification by the polymerase chain reaction was done on the bacterial 16 S ribosomal DNA present in a small-bowel biopsy specimen taken from a patient with Whipple's disease. A search by computer for similar rRNA sequences filed in databases showed the Whipple's-associated organism to be most similar to bacteria of the Rhodococcus, Streptomyces, and Arthrobacter genera, and more weakly related to mycobacteria. The biopsy specimen was estimated to contain around 10(7) cells of the organism. The probable aetiological agent for our patient's illness has not been identified previously in a patient with Whipple's disease.

Full Text

Duke Authors

Cited Authors

  • Wilson, KH; Blitchington, R; Frothingham, R; Wilson, JA

Published Date

  • August 24, 1991

Published In

Volume / Issue

  • 338 / 8765

Start / End Page

  • 474 - 475

PubMed ID

  • 1714530

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/0140-6736(91)90545-z


  • eng

Conference Location

  • England