Optimization of inverse treatment planning using a fuzzy weight function.

Journal Article (Journal Article)

A fuzzy approach has been applied to inverse treatment planning optimization in radiation therapy. The proposed inverse-planning algorithm optimizes both the intensity-modulated beam (IMB) and the normal tissue prescription. In the IMB optimization, we developed a fast-monotonic-descent (FMD) method that has the property of fast and monotonic convergence to the minimum for a constrained quadratic objective function. In addition, a fuzzy weight function is employed to express the vague knowledge about the importance of matching the calculated dose to the prescribed dose in the normal tissue. Then, a validity function is established to optimize the normal tissue prescription. The performance of this new fuzzy prescription algorithm has been compared to that based on hard prescription methods for two treatment geometries. The FMD method presented here both provides a full-analytical solution to the optimization of intensity-modulated beams, and guarantees fast and monotonic convergence to the minimum. It has been shown that the fuzzy inverse planning technique is capable of achieving an optimal balance between the objective of matching the calculated dose to the prescribed dose for the target volume and the objective of minimizing the normal tissue dose.

Full Text

Duke Authors

Cited Authors

  • Li, RP; Yin, FF

Published Date

  • April 2000

Published In

Volume / Issue

  • 27 / 4

Start / End Page

  • 691 - 700

PubMed ID

  • 10798691

International Standard Serial Number (ISSN)

  • 0094-2405

Digital Object Identifier (DOI)

  • 10.1118/1.598931


  • eng

Conference Location

  • United States